Open AccessIntestinal elimination of sparfloxacin, fleroxacin, and ciprofloxacin in rats
Author(s) -
Ethan Rubinstein,
Sophie Dautrey,
R Farinoti,
Louis-Andramp;eacute; Julien,
Jacob Ramon,
C Carbon
Publication year - 1995
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.39.1.99
Subject(s) - fleroxacin , sparfloxacin , ciprofloxacin , ileum , antibacterial agent , antibiotics , daptomycin , medicine , pharmacology , chemistry , microbiology and biotechnology , biology , ofloxacin , staphylococcus aureus , vancomycin , bacteria , genetics
The intestinal transepithelial elimination of sparfloxacin and fleroxacin was compared with that of ciprofloxacin in a rat model following a single parenteral administration of 25 mg of each of the antibiotics per kg of body weight. All three fluoroquinolones were eliminated through the small intestine. Ciprofloxacin was eliminated in the proximal jejunum at a rate of 1.97 +/- 0.70 micrograms/cm2, while the elimination rates of fleroxacin and sparfloxacin were 0.64 +/- 026 and 0.21 +/- 0.10 micrograms/cm2, respectively, over a 90-min collection period. In the ileum, the elimination rates of ciprofloxacin, fleroxacin, and sparfloxacin over the same period were 1.44 +/- 0.77, 1.00 +/- 0.33, and 0.41 +/- 0.26 micrograms/mc2, respectively. These data suggest that these fluoroquinolones undergo a transepithelial elimination process in the small intestine. This route of elimination may be important in the therapy of bacterial diarrhea.