Open AccessHigh efficacy of short-term quinine-antibiotic combinations for treating adult malaria patients in an area in which malaria is hyperendemic
Author(s) -
Wolfram Metzger,
Benjamin Mordmüller,
Wolfgang Graninger,
Ulrich Bienzle,
Peter G. Kremsner
Publication year - 1995
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.39.1.245
Subject(s) - quinine , doxycycline , malaria , plasmodium falciparum , clindamycin , medicine , regimen , antibiotics , pharmacology , biology , immunology , microbiology and biotechnology
In a randomized trial, a three-dose quinine monotherapy was compared with short-term combination regimens of quinine-clindamycin and quinine-doxycycline for treating adult Gabonese patients with Plasmodium falciparum malaria. In quinine-treated patients, only 38% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.