Open AccessEffect of bismuth subsalicylate on ciprofloxacin bioavailability
Author(s) -
L Rambout,
Jan Sahai,
Keith Gallicano,
L Oliveras,
Gary Garber
Publication year - 1994
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.38.9.2187
Subject(s) - bioavailability , ciprofloxacin , pharmacokinetics , medicine , antibacterial agent , gastroenterology , pharmacology , antibiotics , chemistry , biochemistry
A single oral dose of 528 mg of bismuth subsalicylate (30 ml of Pepto-Bismol) had no significant effect on the plasma pharmacokinetics of a single oral dose of 750 mg of ciprofloxacin administered to 12 healthy volunteers (six men and six women). These results suggest that ciprofloxacin bioavailability will not be significantly decreased by single doses of bismuth subsalicylate when the two medications are administered simultaneously.