Open AccessIn vivo bactericidal activities of ciprofloxacin and pefloxacin in an experimental model of Serratia marcescens endocarditis
Author(s) -
Marie Emmanuelle Juvin,
G. Potel,
Jocelyne Caillon,
Yan Xiong,
Denis Bug,
Philippe Le Conte,
D. Baron,
H Drugeon
Publication year - 1994
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.38.4.883
Subject(s) - pefloxacin , serratia marcescens , ciprofloxacin , liter , microbiology and biotechnology , in vivo , antibacterial agent , endocarditis , chemistry , medicine , antibiotics , biology , ofloxacin , surgery , biochemistry , escherichia coli , gene
The critical concentrations of pefloxacin and ciprofloxacin in serum, corresponding to the lowest concentration in serum able to achieve a 2-log-unit reduction in the CFU in vegetations after a 24-h exposure at a steady-state concentration obtained by a continuous intravenous infusion, were determined in an experimental model of Serratia marcescens endocarditis in rabbits. In vitro data showed that the MICs of ciprofloxacin and pefloxacin were 0.06 and 0.25 mg/liter, respectively. The killing curves indicated a maximum killing rate at a concentration four times that of the MICs. In vivo, the critical concentrations of pefloxacin and ciprofloxacin in serum were 0.4 and 0.24 mg/liter, respectively, corresponding to a concentration of four times the MICs.