Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump | Zendy

G G Guay | Zendy; Margareta Tuckman | Zendy; David M. Rothstein | Zendy

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Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump

Author(s) -

G G Guay,

Margareta Tuckman,

David M. Rothstein

Publication year - 1994

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.38.4.857

Subject(s) - tetracycline , efflux , transposable element , mutation , tn10 , gene , minocycline , genetics , biology , microbiology and biotechnology , antibiotics , mutant

The tetA(B) gene from transposon Tn10 fails to mediate resistance to the novel tetracycline analog 9-(dimethylglycylamido)minocycline (DMG-Mino) (P. E. Sum, V. J. Lee, R. T. Testa, J. J. Hlavka, G. A. Ellestad, J. D. Bloom, Y. Gluzman, and F. P. Tally, J. Med. Chem. 37:184-188, 1994; R. T. Testa, P. Petersen, N. V. Jacobus, P. E. Sum, V. J. Lee, and F. P. Tally, Antimicrob. Agents Chemother. 37:2270-2277, 1993). Mutations in either of two codons of tetA(B) that resulted in increased resistance to DMG-Mino also caused diminished resistance to tetracycline, identifying amino acid residues critical for the recognition of tetracycline.

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