In vitro studies on stability and development of metronidazole resistance in Helicobacter pylori | Zendy

Anton A. van Zwet | Zendy; J C Thijs | Zendy; W Schievink-de Vries | Zendy; J. Schiphuis | Zendy; J. Snijder | Zendy

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In vitro studies on stability and development of metronidazole resistance in Helicobacter pylori

Author(s) -

Anton A. van Zwet,

J C Thijs,

W Schievink-de Vries,

J. Schiphuis,

J. Snijder

Publication year - 1994

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.38.2.360

Subject(s) - metronidazole , helicobacter pylori , microbiology and biotechnology , agar dilution , biology , agar dilution method , agar , agar plate , spirillaceae , bacteria , antibiotics , minimum inhibitory concentration , gastritis , genetics

Seventy isolates of Helicobacter pylori from antral biopsy samples were tested for their susceptibilities to metronidazole by agar dilution. Seven (10%) of these clinical isolates appeared to be resistant to metronidazole. Sixty-three strains were susceptible. In 42 (67%) of the 63 susceptible isolates, resistant isolates were obtained by serial passage on plates containing subinhibitory concentrations of metronidazole. In 10 of these 42 strains, the acquired resistance appeared to be unstable. The difference between the stability of resistance that occurred after one or two passages and the stability of resistance that occurred after three passages was statistically significant (P < 0.006). Primary resistance in clinical isolates was a stable phenomenon. Whether the resistance that emerges during therapy in patients is stable or unstable needs to be established.

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