Influence of host cell type and V3 loop of the surface glycoprotein on susceptibility of human immunodeficiency virus type 1 to polyanion compounds | Zendy

Pascal Meylan | Zendy; Richard S. Kornbluth | Zendy; I Zbinden | Zendy; Douglas D. Richman | Zendy

Open Access

Influence of host cell type and V3 loop of the surface glycoprotein on susceptibility of human immunodeficiency virus type 1 to polyanion compounds

Author(s) -

Pascal Meylan,

Richard S. Kornbluth,

I Zbinden,

Douglas D. Richman

Publication year - 1994

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.38.12.2910

Subject(s) - v3 loop , in vitro , virology , biology , glycoprotein , virus , macrophage , cell culture , dextran , viral replication , cell , heparin , heparan sulfate , immunology , antibody , microbiology and biotechnology , biochemistry , genetics , epitope

Dextran sulfate is a potent inhibitor of human immunodeficiency virus (HIV) binding and replication in lymphocytic cell lines. In this study, we demonstrate that the effect of dextran sulfate and heparin depends on the host cell type and on the V3 loop, the principal neutralizing determinant of HIV gp120. In particular, when dextran sulfate was tested on primary human macrophages infected with macrophage-tropic viruses, enhancement of infection was observed in 6 of 11 independent macrophage preparations and with 5 of 13 primary HIV isolates. Our in vitro observations might explain why enhanced HIV replication was observed in HIV-infected patients treated with dextran sulfate.

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