Open AccessIn vitro killing activities of antibiotics at clinically achievable concentrations in cerebrospinal fluid against penicillin-resistant Streptococcus pneumoniae isolated from children with meningitis
Author(s) -
Catherine Doit,
Stéphane Bonacorsi,
A. Frémaux,
G. Sissia,
Robert Cohen,
P. Geslin,
Édouard Bingen
Publication year - 1994
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.38.11.2655
Subject(s) - fosfomycin , imipenem , penicillin , microbiology and biotechnology , streptococcus pneumoniae , antibiotics , vancomycin , meningitis , gentamicin , cerebrospinal fluid , medicine , antibacterial agent , biology , bacteria , antibiotic resistance , staphylococcus aureus , surgery , genetics
We evaluated the in vitro killing activities of ceftriaxone, imipenem, vancomycin, gentamicin, fosfomycin, and rifampin, alone and in combination, against 26 Streptococcus pneumoniae strains (penicillin G MICs, > 0.125 to 2 micrograms/ml) isolated from the cerebrospinal fluid of children with meningitis. The antibiotics were tested at clinically achievable concentrations in cerebrospinal fluid. After 5 h of incubation, imipenem was the most effective drug. None of the combinations had synergistic activity. Killing by beta-lactam antibiotics or vancomycin was enhanced by the addition of gentamicin, reduced by the addition of rifampin, and unaffected by the addition of fosfomycin.