Open AccessAzole resistance in oropharyngeal Candida albicans strains isolated from patients infected with human immunodeficiency virus
Author(s) -
Xiaoyi He,
Robert N. Tiballi,
Lidija T. Zarins,
Suzanne Bradley,
Jon A. Sangeorzan,
Carol A. Kauffman
Publication year - 1994
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.38.10.2495
Subject(s) - itraconazole , fluconazole , azole , microbiology and biotechnology , candida albicans , mycosis , biology , fungi imperfecti , drug resistance , virology , antifungal , immunology
For 212 oropharyngeal isolates of Candida albicans, the fluconazole MICs for 50 and 90% of strains tested were 0.5 and 16 micrograms/ml, respectively, and those of itraconazole were 0.05 and 0.2 micrograms/ml, respectively. Of 16 isolates for which fluconazole MICs were > 64 micrograms/ml, itraconazole MICs for 14 were 6.4 micrograms/ml. Most fluconazole-resistant strains remained susceptible to itraconazole; whether itraconazole will prove effective for refractory thrush remains to be shown.