Open AccessAerosol amphotericin B for prevention of invasive pulmonary aspergillosis
Author(s) -
Jörg Beyer,
G. Barzen,
G. Risse,
Christian Weyer,
Klaus Miksits,
Klaus Dullenkopf,
D. Huhn,
W. Siegert
Publication year - 1993
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.37.6.1367
Subject(s) - amphotericin b , aspergillosis , pharmacokinetics , aerosol , medicine , drug , pharmacology , absorption (acoustics) , immunology , chemistry , dermatology , antifungal , materials science , organic chemistry , composite material
The pharmacokinetics and applicability of aerosol amphotericin B administrations were studied in 40 neutropenic patients and 4 healthy volunteers. Particle size was measured and pulmonary deposition was demonstrated by radioisotope studies. Inhalations were easy to administer and were well tolerated, with minimal systemic absorption of the drug.