In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth | Zendy

James A. Karlowsky | Zendy; George G. Zhanel | Zendy; Ross Davidson | Zendy; Shelley Zieroth | Zendy; D. J. Hoban | Zendy

Open Access

In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth

Author(s) -

James A. Karlowsky,

George G. Zhanel,

Ross Davidson,

Shelley Zieroth,

D. J. Hoban

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.5.1154

Subject(s) - cefotaxime , gentamicin , ciprofloxacin , microbiology and biotechnology , cerebrospinal fluid , escherichia coli , antibacterial agent , antibiotics , enterobacteriaceae , chemistry , biology , biochemistry , neuroscience , gene

Multiple exposures with cefotaxime in either Mueller-Hinton broth or cerebrospinal fluid had no effect on killing or the duration of postantibiotic effect (PAE) in Escherichia coli strains tested. However, upon multiple exposures in Mueller-Hinton broth, ciprofloxacin and gentamicin PAEs significantly decreased with a concomitant reduction in bacterial killing. A reduction in bacterial killing following multiple ciprofloxacin and gentamicin exposures was also seen with cerebrospinal fluid; however, the PAE was maintained.

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