3'-azido-3'-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA | Zendy

Joan A. Harrington | Zendy; John E. Reardon | Zendy; T Spector | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

3'-azido-3'-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA

Author(s) -

Joan A. Harrington,

John E. Reardon,

T Spector

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.4.918

Subject(s) - exonuclease , dna , zidovudine , exonuclease iii , microbiology and biotechnology , biochemistry , chemistry , thymidine , dna polymerase , biology , virology , escherichia coli , human immunodeficiency virus (hiv) , viral disease , gene

A 3'-exonuclease(s) that excised 3'-azido-3'-deoxythymidine (AZT) monophosphate (AZTMP) from the 3' terminus of DNA was partially purified from two human cell lines. AZTMP inhibited the hydrolysis of AZTMP-terminated single-stranded and double-stranded DNA substrates. Thus, high levels of AZTMP might inhibit the exonuclease and trigger the toxicity of AZT by impairing the repair of AZTMP-terminated DNA.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research