In vitro activities of ramoplanin, selected glycopeptides, fluoroquinolones, and other antibiotics against clinical bloodstream isolates of gram-positive cocci | Zendy

Theresa Lawrence | Zendy; Coleman Rotstein | Zendy; Thomas R. Beam | Zendy; E. A. Gorzynski | Zendy; Daniel Amsterdam | Zendy

Open Access

In vitro activities of ramoplanin, selected glycopeptides, fluoroquinolones, and other antibiotics against clinical bloodstream isolates of gram-positive cocci

Author(s) -

Theresa Lawrence,

Coleman Rotstein,

Thomas R. Beam,

E. A. Gorzynski,

Daniel Amsterdam

Publication year - 1993

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.37.4.896

Subject(s) - glycopeptide , microbiology and biotechnology , gram positive cocci , antibiotics , vancomycin , enterococcus , gram positive bacteria , biology , medicine , bacteria , staphylococcus aureus , genetics

The susceptibilities of 316 gram-positive bacteremic isolates to ramoplanin, vancomycin, and teicoplanin and seven other antibiotics were tested. Ramoplanin demonstrated MICs of < or = 0.25 microgram/ml for at least 99% of Staphylococcus aureus isolates and 100% of coagulase-negative staphylococci tested. For both oxacillin-susceptible and oxacillin-resistant S. aureus and coagulase-negative staphylococci, the activity of ramoplanin surpassed those of both vancomycin and teicoplanin. Ramoplanin and teicoplanin had comparable activities against enterococci and Streptococcus pneumoniae and were superior to vancomycin.

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