Open AccessChanges in adherence of respiratory pathogens to HEp-2 cells induced by subinhibitory concentrations of sparfloxacin, ciprofloxacin, and trimethoprim
Author(s) -
Maarten R. Visser,
H.M. Beumer,
A. I. M. Hoepelman,
M. Rozenberg-Arska,
J. Verhoef
Publication year - 1993
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.37.4.885
Subject(s) - sparfloxacin , microbiology and biotechnology , streptococcus pneumoniae , ciprofloxacin , moraxella catarrhalis , klebsiella pneumoniae , haemophilus influenzae , trimethoprim , moraxella , pseudomonas aeruginosa , antimicrobial , antibacterial agent , moraxella (branhamella) catarrhalis , biology , antibiotics , bacteria , ofloxacin , escherichia coli , genetics , biochemistry , gene
Preincubation with subinhibitory concentrations of sparfloxacin, ciprofloxacin, and trimethoprim decreased the adherence of the respiratory pathogens Klebsiella pneumoniae, Haemophilus influenzae, and Moraxella (Branhamella) catarrhalis to human larynx carcinoma HEp-2 cells. Subinhibitory concentrations of sparfloxacin did not change the adherence of Pseudomonas aeruginosa or Streptococcus pneumoniae 15.62, but adhesion of S. pneumoniae 15.42 was significantly enhanced by subinhibitory antimicrobial concentrations.