Open AccessSusceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid
Author(s) -
Judah L. Rosner
Publication year - 1993
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.37.10.2251
Subject(s) - regulon , escherichia coli , isoniazid , microbiology and biotechnology , mutant , salmonella , mycobacterium tuberculosis , biology , sos response , chemistry , biochemistry , bacteria , tuberculosis , gene , medicine , genetics , pathology
Escherichia coli and Salmonella typhimurium are normally resistant to > 500 micrograms of the antituberculosis drug isonicotinic acid hydrazide (isoniazid; INH) per ml. Susceptibility to INH (< 50 micrograms/ml) has now been found for mutants that are deficient in OxyR, the oxidative stress response regulator. Two OxyR-regulated enzymes, alkyl hydroperoxide reductase and hydroperoxidase I, were identified as playing important roles in INH resistance. OxyR regulon mutants should be useful for identifying other determinants of INH resistance in both E. coli and Mycobacterium tuberculosis and for finding new INH-like drugs.