In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2 | Zendy

Adriana Weinberg | Zendy; B J Bate | Zendy; Helen Masters | Zendy; Sergej Schneider | Zendy; Julia C. Clark | Zendy; C G Wren | Zendy; Jane Allaman | Zendy; Myron J. Levin | Zendy

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In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2

Author(s) -

Adriana Weinberg,

B J Bate,

Helen Masters,

Sergej Schneider,

Julia C. Clark,

C G Wren,

Jane Allaman,

Myron J. Levin

Publication year - 1992

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.36.9.2037

Subject(s) - penciclovir , herpes simplex virus , virology , famciclovir , aciclovir , in vitro , virus , guanine , microgram , biology , herpesviridae , viral disease , nucleotide , biochemistry , gene

Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-fold less HSV than acyclovir-treated cultures, consistent with the prolonged intracellular half-life of PCV triphosphate.

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