Open AccessIn vitro susceptibilities of Borrelia burgdorferi to five oral cephalosporins and ceftriaxone
Author(s) -
William A. Agger,
Steven M. Callister,
Dean A. Jobe
Publication year - 1992
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.36.8.1788
Subject(s) - cefixime , cefaclor , ceftriaxone , cephalosporin , cefuroxime , microbiology and biotechnology , borrelia burgdorferi , cefadroxil , microgram , antibacterial agent , antibiotics , chemistry , in vitro , medicine , biology , immunology , biochemistry , antibody
We determined the in vitro susceptibilities of eight Borrelia burgdorferi isolates to five oral cephalosporins. MICs for B. burgdorferi 297 were 23 micrograms/ml (cephalexin), 45 micrograms/ml (cefadroxil), 91 micrograms/ml (cefaclor), 0.13 microgram/ml (cefuroxime), 0.8 microgram/ml (cefixime), and 0.02 microgram/ml (ceftriaxone). When B. burgdorferi isolates were exposed to concentrations twice the MIC of cefuroxime, cefixime, or ceftriaxone, at least 72 h of incubation was required to kill 99% of the organisms.