Analysis of vancomycin time-kill studies with Staphylococcus species by using a curve stripping program to describe the relationship between concentration and pharmacodynamic response | Zendy

Bruce H. Ackerman | Zendy; Ann M. Vannier | Zendy; E B Eudy | Zendy

Open Access

Analysis of vancomycin time-kill studies with Staphylococcus species by using a curve stripping program to describe the relationship between concentration and pharmacodynamic response

Author(s) -

Bruce H. Ackerman,

Ann M. Vannier,

E B Eudy

Publication year - 1992

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.36.8.1766

Subject(s) - staphylococcus aureus , vancomycin , staphylococcus , pharmacodynamics , microbiology and biotechnology , coagulase , micrococcaceae , nonlinear regression , antibacterial agent , chemistry , biology , antibiotics , chromatography , bacteria , pharmacokinetics , pharmacology , regression analysis , mathematics , statistics , genetics

Mono- and biexponential killing curves for vancomycin over a 2- to 50-micrograms/ml concentration range were generated for 11 Staphylococcus aureus isolates and 12 coagulase-negative Staphylococcus species in the logarithmic phase of growth. Nonlinear least-squares regression of the initial growth rate and disappearance were not significantly different for lower or higher concentrations of vancomycin in broth.

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