Open AccessTet determinants provide poor protection against some tetracyclines: further evidence for division of tetracyclines into two classes
Author(s) -
B Oliva,
Ian Chopra
Publication year - 1992
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.36.4.876
Subject(s) - efflux , escherichia coli , staphylococcus aureus , microbiology and biotechnology , biology , tetracycline , antibiotics , chemistry , bacteria , genetics , gene
Atypical tetracyclines were active against Escherichia coli and Staphylococcus aureus strains containing determinants that mediate resistance to typical tetracyclines by efflux (Tet B and Tet K) or ribosomal protection (Tet M) mechanisms. The results support recently published data that tetracyclines are divisible into at least two classes on the basis of their modes of action.