Open AccessDistribution of ciprofloxacin in ascitic fluid following administration of a single oral dose of 750 milligrams
Author(s) -
Michael Dan,
T. Zuabi,
C. Quassem,
Heschi H. Rotmensch
Publication year - 1992
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.36.3.677
Subject(s) - ciprofloxacin , spontaneous bacterial peritonitis , ascitic fluid , oral administration , peritonitis , antibacterial agent , pharmacokinetics , oral dose , medicine , peritoneal fluid , pharmacology , antibiotics , ascites , chemistry , gastroenterology , microbiology and biotechnology , biology
The penetration of ciprofloxacin into the ascitic fluid of eight patients was studied. Serum and ascitic fluid samples were obtained before and at 1, 2, 3, 6, and 12 h following administration of a single oral dose of 750 mg. Peak levels (mean +/- standard deviation) were 4.0 +/- 0.7 micrograms/ml in serum and 2.6 +/- 0.6 micrograms/ml in ascitic fluid; the areas under the curve (0 to 12 h) were 29.1 +/- 6.5 micrograms.h/ml in serum and 20.7 +/- 5.0 micrograms.h/ml in ascitic fluid. The concentrations that were achieved are well above the MICs of ciprofloxacin for the members of the family Enterobacteriaceae that cause spontaneous bacterial peritonitis.