Open AccessThe multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein
Author(s) -
Alexander A. Neyfakh
Publication year - 1992
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.36.2.484
Subject(s) - efflux , bacillus subtilis , staphylococcus aureus , microbiology and biotechnology , multiple drug resistance , transporter , staphylococcus , biology , gene , antibiotics , chemistry , bacteria , biochemistry , genetics
The Bacillus subtilis multidrug efflux transporter Bmr demonstrates 44% amino acid sequence identity with a product of the Staphylococcus aureus gene norA, which is responsible for clinically relevant resistance to fluoroquinolones. We show here that overexpression of bmr in B. subtilis provides strong resistance to fluoroquinolones that can be reversed by reserpine, an inhibitor of Bmr.