Open AccessSurvey of Bacteroides fragilis group susceptibility patterns in Canada
Author(s) -
Anne–Marie Bourgault,
F Lamothe,
Daryl J. Hoban,
Mary Dalton,
Pamela Kibsey,
G. K. M. Harding,
John A. Smith,
Low D,
Huguette Gilbert
Publication year - 1992
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.36.2.343
Subject(s) - ceftizoxime , cefotetan , ticarcillin , bacteroides fragilis , microbiology and biotechnology , piperacillin , cefoxitin , moxalactam , imipenem , mezlocillin , bacteroides thetaiotaomicron , sulbactam , cefoperazone , penicillin , tazobactam , biology , bacteroides , antibiotics , cephalosporin , antibiotic resistance , pseudomonas aeruginosa , bacteria , genetics , staphylococcus aureus
The in vitro activities of penicillin, clindamycin, chloramphenicol, metronidazole, piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin-sulbactam, cefoxitin, ceftizoxime, cefotetan, moxalactam, and imipenem against 348 Bacteroides fragilis group isolates collected from six Canadian cities during 1990 were determined by the National Committee for Clinical Laboratory Standards (NCCLS) agar dilution technique. All isolates were susceptible to chloramphenicol, metronidazole, piperacillin-tazobactam, and imipenem. For the other antibiotics tested, the following resistance rates were observed: penicillin, 97%; clindamycin, 9%; piperacillin, 19%; ticarcillin, 31%; ticarcillin-clavulanate, 0.28%; ampicillin-sulbactam, 0.85%; cefoxitin, 26%; ceftizoxime, 15%; cefotetan, 53%; and moxalactam, 17%. Susceptibility profiles to beta-lactam antibiotics varied among the different species tested: B. fragilis and Bacteroides vulgatus demonstrated lower resistance rates than Bacteroides distasonis and indole-positive Bacteroides thetaiotaomicron and Bacteroides ovatus. Ceftizoxime results should be interpreted cautiously, because the MICs obtained with the recommended NCCLS control strain were lower than expected.