Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa | Zendy

E B Jakics | Zendy; Shizuko Iyobe | Zendy; Keiji Hirai | Zendy; Hideyuki Fukuda | Zendy; H Hashimoto | Zendy

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Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa

Author(s) -

E B Jakics,

Shizuko Iyobe,

Keiji Hirai,

Hideyuki Fukuda,

H Hashimoto

Publication year - 1992

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.36.11.2562

Subject(s) - pseudomonas aeruginosa , norfloxacin , biology , microbiology and biotechnology , plasmid , antibacterial agent , chloramphenicol , mutation , antibiotics , genetics , bacteria , dna , ciprofloxacin , gene

Seven spontaneous norfloxacin (NFLX)-resistant mutants obtained in vitro from 20 NFLX-susceptible clinical isolates and 3 NFLX-resistant clinical isolates of Pseudomonas aeruginosa were transformed with the pNF111 plasmid, whose BamHI fragment is responsible for conferring susceptibility to NFLX, by complementing the nfxB mutation. The resulting patterns of MICs of NFLX, beta-lactams, aminoglycosides, and chloramphenicol and the observed increased accumulation of NFLX were consistent with the occurrence of the nfxB type mutation in these clinical isolates.

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