Effect of inoculum size on bacteriolytic activity of cefminox and four other beta-lactam antibiotics against Escherichia coli | Zendy

Francisco García Soriano | Zendy; Richard Edwards | Zendy; David Greenwood | Zendy

Open Access

Effect of inoculum size on bacteriolytic activity of cefminox and four other beta-lactam antibiotics against Escherichia coli

Author(s) -

Francisco García Soriano,

Richard Edwards,

David Greenwood

Publication year - 1992

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.36.1.223

Subject(s) - cefoxitin , ceftizoxime , imipenem , cefotaxime , microbiology and biotechnology , escherichia coli , antibiotics , spheroplast , antibacterial agent , moxalactam , enterobacteriaceae , cephalosporin , biology , beta lactamase , cefotiam , chemistry , bacteria , biochemistry , staphylococcus aureus , antibiotic resistance , gene , genetics

MICs and turbidimetric experiments revealed a negligible inoculum effect with two Escherichia coli strains exposed to cefminox and cefoxitin, whereas a marked inoculum effect was revealed after exposure to cefotaxime, ceftizoxime, and imipenem. The activities of the cephamycins were associated with spheroplast formation and bacteriolysis at concentrations close to the MIC, whereas the other agents induced the formation of filaments or, in the case of imipenem, rounded cells.

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