Open AccessUse of slime dispersants to promote antibiotic penetration through the extracellular polysaccharide of mucoid Pseudomonas aeruginosa
Author(s) -
C. Gordon,
Norman Hodges,
Christopher Marriott
Publication year - 1991
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.35.6.1258
Subject(s) - pseudomonas aeruginosa , gentamicin , microbiology and biotechnology , antibiotics , ceftazidime , dispersant , penetration (warfare) , chemistry , extracellular , extracellular polymeric substance , gentamicin sulfate , diffusion , pseudomonas , bacteria , biofilm , biology , biochemistry , dispersion (optics) , genetics , physics , optics , operations research , engineering , thermodynamics
Agents with the potential to reduce Pseudomonas aeruginosa alginate viscosity (slime dispersants) were shown to promote the diffusion of antipseudomonal antibiotics through alginate but were more effective in facilitating the diffusion of gentamicin than that of ceftazidime. EDTA increased the diffusion rates of these antibiotics by factors of 4.0 and 1.5, respectively, although sodium chloride significantly reduced viscosity and enhanced gentamicin diffusion.