Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm | Zendy

Birgit Giwercman | Zendy; Erik Jensen | Zendy; Niels Høiby | Zendy; A. Kharazmi | Zendy; J. W. Costerton | Zendy

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Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm

Author(s) -

Birgit Giwercman,

Erik Jensen,

Niels Høiby,

A. Kharazmi,

J. W. Costerton

Publication year - 1991

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.35.5.1008

Subject(s) - biofilm , pseudomonas aeruginosa , microbiology and biotechnology , piperacillin , imipenem , beta lactamase , pseudomonadales , pseudomonadaceae , bacteria , pseudomonas , beta (programming language) , biology , chemistry , escherichia coli , biochemistry , genetics , gene , computer science , programming language

Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.

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