Open AccessInduction of beta-lactamase production in Pseudomonas aeruginosa biofilm
Author(s) -
Birgit Giwercman,
Elsebeth Tvenstrup Jensen,
Niels Høiby,
Arsalan Kharazmi,
J. W. Costerton
Publication year - 1991
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.35.5.1008
Subject(s) - biofilm , pseudomonas aeruginosa , microbiology and biotechnology , piperacillin , imipenem , beta lactamase , pseudomonadales , pseudomonadaceae , bacteria , pseudomonas , beta (programming language) , biology , chemistry , escherichia coli , biochemistry , genetics , gene , computer science , programming language
Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.