Activities of various macrolide antibiotics against Mycobacterium leprae infection in mice | Zendy

R H Gelber | Zendy; P Siu | Zendy; M Tsang | Zendy; L P Murray | Zendy

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Activities of various macrolide antibiotics against Mycobacterium leprae infection in mice

Author(s) -

R H Gelber,

P Siu,

M Tsang,

L P Murray

Publication year - 1991

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.35.4.760

Subject(s) - roxithromycin , clarithromycin , azithromycin , erythromycin , macrolide antibiotics , microbiology and biotechnology , antibiotics , mycobacterium leprae , antibacterial agent , biology , medicine , leprosy , immunology

We evaluated the activities of several macrolide antibiotics against M. leprae infections in mouse footpads. Erythromycin and azithromycin were inactive, while both roxithromycin and clarithromycin were found to be consistently active and, in fact, bactericidal. By both methods, clarithromycin was found to be superior to roxithromycin, a finding which, at least in part, may be a consequence of the higher levels of clarithromycin at the site of infection.

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