Open AccessIn vitro activity of sparfloxacin
Author(s) -
Nai-Xun Chin,
JianWei Gu,
K. W. Yu,
Y X Zhang,
Harold C. Neu
Publication year - 1991
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.35.3.567
Subject(s) - sparfloxacin , ofloxacin , ciprofloxacin , microbiology and biotechnology , streptococcus pneumoniae , bacteroides fragilis , lomefloxacin , antibacterial agent , streptococcus pyogenes , pseudomonas aeruginosa , streptococcaceae , biology , staphylococcus aureus , chemistry , antibiotics , bacteria , genetics
Sparfloxacin, a new fluoroquinolone, inhibited the majority of members of the family Enterobacteriaceae at less than or equal to 1 microgram/ml. It was less active than ciprofloxacin but more active than ofloxacin. Against Pseudomonas aeruginosa, it was less active than ciprofloxacin but twofold more active than ofloxacin. It inhibited Staphylococcus aureus and most Streptococcus pneumoniae and Streptococcus pyogenes isolates at 0.25 micrograms/ml, whereas ciprofloxacin and ofloxacin inhibited these isolates at 2 micrograms/ml. Bacteroides fragilis was inhibited by less than or equal to 2 micrograms/ml. Sparfloxacin was less active at an acidic pH and in the presence of Mg2+. Resistance to sparfloxacin was produced by repeated exposure, although the frequency of single-step mutants was less than 10(-9).