Induction of a class I beta-lactamase from Citrobacter freundii in Escherichia coli requires active ftsZ but not ftsA or ftsQ products | Zendy

Abramo C. Ottolenghi | Zendy; Juan A. Ayala | Zendy

Open Access

Induction of a class I beta-lactamase from Citrobacter freundii in Escherichia coli requires active ftsZ but not ftsA or ftsQ products

Author(s) -

Abramo C. Ottolenghi,

Juan A. Ayala

Publication year - 1991

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.35.11.2359

Subject(s) - escherichia coli , citrobacter freundii , ftsz , mutant , cefoxitin , enterobacteriaceae , biology , microbiology and biotechnology , sos response , novobiocin , beta (programming language) , gene , bacteria , biochemistry , genetics , antibiotics , staphylococcus aureus , computer science , programming language

A possible connection between septation/division and induction of cloned ampC beta-lactamase was investigated. When a ftsZ84(Ts) mutant of Escherichia coli carrying ampR-ampC from Citrobacter freundii was grown at the restrictive temperature (42 degrees C), induction of beta-lactamase by cefoxitin was inhibited by about 80%. Inhibition was virtually complete when a ftsZ84(Ts) mutant of different genetic background was tested. Although somewhat delayed, the induction of beta-lactamase in transformed ftsA(Ts) and ftsQ(Ts) mutants was similar to that observed in wild-type transformants. These results imply that FtsZ is involved in the process of beta-lactamase induction.

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