Open AccessActivity of compound G2 isolated from alfalfa roots in experimental dermatophyte infection
Author(s) -
Ruth Evron,
Miriam Guizie,
Uri Zehavi,
Itzhack Polacheck
Publication year - 1990
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.34.8.1600
Subject(s) - dermatophyte , trichophyton , biology , guinea pig , microbiology and biotechnology , medicine , antifungal
Compound G2 isolated from alfalfa roots was applied topically to skin lesions of guinea pigs experimentally infected with the dermatophyte Trichophyton mentagrophytes var. granulare. After 12 to 15 applications, 80% of the infected lesions were cured, as judged by clinical and microbial criteria, compared with 20% of the untreated lesions which healed spontaneously (P less than 0.01).