Open AccessEffective chemotherapy of equine herpesvirus 1 by phosphonylmethoxyalkyl derivatives of adenine demonstrated in a novel murine model for the disease
Author(s) -
Hugh J. Field,
Aftab Awan
Publication year - 1990
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.34.5.709
Subject(s) - viremia , virus , virology , chemotherapy , biology , respiratory tract , viral replication , herpesviridae , immunology , respiratory system , viral disease , genetics , anatomy
Equine herpesvirus 1 was established in adult mice by means of intranasal inoculation. A disease developed that showed several features closely resembling the infection in the natural host. These included the restriction of virus replication to the respiratory tract and blood, the replication of virus in ciliated mucosa, and development of viremia for several days during the acute phase of the infection. Infected mice were treated with the antiviral agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine. A marked effect was observed on virus replication in the respiratory tract when chemotherapy was commenced 1 day before virus inoculation; it also cleared the viremia and reversed the progression of clinical signs. When chemotherapy was commenced 1 day after virus inoculation, a moderate, though less marked effect was observed. The efficacy of this drug in the murine infection correlated with activity of the drug against equine herpesvirus 1 in cell cultures. The prospects for chemotherapy in the natural host are discussed in the light of these findings.