Open AccessRandomized, double-blind trial of cefonicid and nafcillin in the treatment of skin and skin structure infections
Author(s) -
Jennifer S. Daly,
Michael Worthington,
Russell J. Andrews,
Rebecca Brown,
Robert A. Schwartz,
Daniel J. Sexton
Publication year - 1990
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.34.4.654
Subject(s) - nafcillin , medicine , randomized controlled trial , clinical trial , double blind , cephalosporin , dermatology , surgery , antibiotics , penicillin , microbiology and biotechnology , placebo , alternative medicine , pathology , biology
We compared treatment with one daily intravenous dose of cefonicid and multidose nafcillin in 65 patients with severe infections of the skin or skin structure. Clinical cure or improvement was achieved in 91% of the patients given cefonicid and in 87% of the patients given nafcillin (P = 0.97). The use of cefonicid may allow outpatient therapy of some severe infections.