Comparative in vitro activities of several new fluoroquinolones and beta-lactam antimicrobial agents against community isolates of Streptococcus pneumoniae | Zendy

Tony Mazzulli | Zendy; Andrew E. Simor | Zendy; R. Jaeger | Zendy; S. Adam Fuller | Zendy; Donald E. Low | Zendy

Open Access

Comparative in vitro activities of several new fluoroquinolones and beta-lactam antimicrobial agents against community isolates of Streptococcus pneumoniae

Author(s) -

Tony Mazzulli,

Andrew E. Simor,

R. Jaeger,

S. Adam Fuller,

Donald E. Low

Publication year - 1990

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.34.3.467

Subject(s) - broth microdilution , streptococcus pneumoniae , ciprofloxacin , microbiology and biotechnology , antimicrobial , ofloxacin , penicillin , antibacterial agent , streptococcaceae , biology , beta lactam , minimum inhibitory concentration , antibiotics

The in vitro susceptibilities of 551 community isolates of Streptococcus pneumoniae from the Canadian province of Ontario to several new fluoroquinolones and beta-lactam antimicrobial agents were determined by a broth microdilution technique. Eight (1.5%) of these isolates were moderately susceptible (MICs, greater than or equal to 0.12 and less than or equal to 1.0 microgram/ml) to penicillin; none was resistant. Temafloxacin, ciprofloxacin, and ofloxacin (MICs for 90% of strains tested, between 1 and 2 micrograms/ml) were the most active fluoroquinolones tested, and BMY-28100 (MIC for 90% of strains tested, 0.25 microgram/ml) was the most active of the new beta-lactams tested.

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