In vitro activity of cefpodoxime proxetil (U-76,252; CS-807) against Neisseria gonorrhoeae | Zendy

Ronda D. Schaadt | Zendy; Betty H. Yagi | Zendy; Gary E. Zurenko | Zendy

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In vitro activity of cefpodoxime proxetil (U-76,252; CS-807) against Neisseria gonorrhoeae

Author(s) -

Ronda D. Schaadt,

Betty H. Yagi,

Gary E. Zurenko

Publication year - 1990

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.34.2.371

Subject(s) - cefpodoxime , neisseria gonorrhoeae , microbiology and biotechnology , cephalosporin , cefuroxime , ceftriaxone , antibacterial agent , antibiotics , penicillin , biology

Cefpodoxime proxetil is an oral cephalosporin antibiotic. The in vitro activities of cefpodoxime (the active metabolite of cefpodoxime proxetil), ceftriaxone, and cefuroxime against both antibiotic-susceptible and antibiotic-resistant clinical isolates of Neisseria gonorrhoeae were determined. Cefpodoxime inhibited all penicillin-susceptible strains and penicillinase-producing strains at less than or equal to 0.015 microgram/ml; chromosomally resistant strains were inhibited by cefpodoxime at less than or equal to 0.125 microgram/ml.

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