Open AccessIdentification of a group of Haemophilus influenzae penicillin-binding proteins that may have complementary physiological roles
Author(s) -
François Malouin,
Thomas Parr,
L. E. Bryan
Publication year - 1990
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.34.2.363
Subject(s) - moxalactam , penicillin binding proteins , cefotaxime , haemophilus influenzae , haemophilus , microbiology and biotechnology , penicillin , piperacillin , antibiotics , cephalosporin , chemistry , biology , bacteria , pseudomonas aeruginosa , genetics
[35S]penicillin bound to different Haemophilus influenzae proteins in assays performed at 20, 37, or 42 degrees C. Penicillin-binding proteins 3a, 3b, 4, and 4' formed a group characterized by their affinity for moxalactam, cefotaxime, and piperacillin. Penicillin-binding protein 4' showed specific properties that may reflect its complementary role in septation.