Open AccessPoliovirus-mediated entry of pokeweed antiviral protein
Author(s) -
T Lee,
M Crowell,
Michael H. Shearer,
Gary M. Aron,
James D. Irvin
Publication year - 1990
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.34.10.2034
Subject(s) - poliovirus , capsid , virology , multiplicity of infection , biology , hela , virus , antiviral protein , cell , microbiology and biotechnology , rna , biochemistry , gene
Infection of HeLa cells with poliovirus results in cell permeabilization to pokeweed antiviral protein. Cell permeabilization was dependent on the integrity of virus capsid proteins and directly proportional to the multiplicity of infection. This study demonstrates that virus adsorption is sufficient for the entry of pokeweed antiviral protein into poliovirus-infected cells.