Open AccessCeftriaxone-netilmicin combination in single-daily-dose treatment of experimental Escherichia coli endocarditis
Author(s) -
Bruno Fantin,
B. Pangon,
G. Potel,
J M Vallois,
François Caron,
A Buré,
C Carbon
Publication year - 1989
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.33.5.767
Subject(s) - netilmicin , aminoglycoside , ceftriaxone , in vivo , cephalosporin , medicine , pharmacology , endocarditis , antibiotics , escherichia coli , antibacterial agent , microbiology and biotechnology , chemistry , gentamicin , biology , tobramycin , biochemistry , gene
We evaluated the activities of ceftriaxone (15 mg/kg), netilmicin (6 mg/kg), and their combination given intramuscularly once daily for 4 days for the treatment of experimental Escherichia coli endocarditis in rabbits. In vitro, a greater rate of killing and an increased trough serum bactericidal titer (P less than 0.01) were achieved with the combination. In vivo, the combination had a greater bactericidal effect (P less than 0.01) and resulted in a greater number of sterile vegetations (P less than 0.05) than single-drug therapy. Thus, in vivo, an increased effect can be obtained despite a single daily dose of a long-acting cephalosporin and an aminoglycoside.