Open AccessActivity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis
Author(s) -
Richard Tucker,
L H Hanson,
Elmer Brummer,
David A. Stevens
Publication year - 1989
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.33.4.573
Subject(s) - ketoconazole , blastomycosis , blastomyces dermatitidis , blastomyces , azole , triazole , pharmacology , itraconazole , medicine , in vitro , mycosis , microbiology and biotechnology , biology , antifungal , immunology , chemistry , biochemistry , organic chemistry
ICI 195,739, a novel orally active triazole, proved 50 times as potent as ketoconazole, produced a clinical cure, and completely eradicated residual infection in a murine model of pulmonary blastomycosis. No other previously tested azole has shown similar activity. Fungicidal activity against Blastomyces dermatitidis was seen in vitro at concentrations 1/40 of those achieved in serum with protective doses.