Open AccessEnhanced gentamicin killing of Escherichia coli by tet gene expression
Author(s) -
Toby L. Merlin,
D L Corvo,
Jason H. Gill,
Jeffrey K. Griffith
Publication year - 1989
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.33.2.230
Subject(s) - gentamicin , tetracycline , escherichia coli , microbiology and biotechnology , biology , gene expression , enterobacteriaceae , antibiotics , gene , genetics
Time-kill studies were performed to determine the effect of tetracycline resistance (tet) gene expression on gentamicin killing of Escherichia coli. Expression of tet increased gentamicin killing in laboratory strains and clinical isolates. A role for tetracycline in inducing tet expression and increasing the bactericidal activity of aminoglycosides is suggested.