Open AccessIn vitro and in vivo activities of atalaphillinine and related acridone alkaloids against rodent malaria
Author(s) -
Hisashi Fujioka,
Yukihiro Nishiyama,
Hiroshi Furukawa,
Nobuo Kumada
Publication year - 1989
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.33.1.6
Subject(s) - acridone , plasmodium berghei , plasmodium yoelii , in vivo , in vitro , pharmacology , malaria , biology , plasmodium falciparum , alkaloid , plasmodium (life cycle) , rutaceae , parasite hosting , traditional medicine , chemistry , parasitemia , biochemistry , medicine , immunology , botany , microbiology and biotechnology , stereochemistry , world wide web , computer science
Thirty acridone alkaloids obtained from Citrus, Glycosmis, or Severinia plants (members of the family Rutaceae) were tested for their antimalarial activities in vitro and in vivo. At a concentration of 10 micrograms/ml in vitro, seven of these alkaloids suppressed 90% or more of Plasmodium yoelii, which causes malaria in rodents. Atalaphillinine, when injected intraperitoneally in a daily dose of 50 mg/kg for 3 days into mice infected with 10(7) erythrocytes parasitized with Plasmodium berghei or Plasmodium vinckei, completely suppressed the development of malaria parasites, with there being no obvious acute toxic effects from the tested dose.