Open AccessOuter membrane alterations in multiresistant mutants of Pseudomonas aeruginosa selected by ciprofloxacin
Author(s) -
Nicholas J. Legakis,
L. S. Tzouvelekis,
Antonios M. Makris,
Helen Kotsifaki
Publication year - 1989
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.33.1.124
Subject(s) - ciprofloxacin , pseudomonas aeruginosa , bacterial outer membrane , microbiology and biotechnology , mutant , pseudomonadales , pseudomonadaceae , antibacterial agent , chemistry , biology , antibiotics , bacteria , escherichia coli , biochemistry , gene , genetics
Spontaneous mutants of Pseudomonas aeruginosa selected by ciprofloxacin were studied for outer membrane alterations. Acquisition of ciprofloxacin resistance was at least partially related to defects in lipopolysaccharide synthesis. When ciprofloxacin resistance was combined with resistance to beta-lactams and aminoglycosides, several alterations in outer membrane proteins were noted.