Open AccessAntibacterial effect of etoposide in vitro
Author(s) -
Wim Calame,
Ron Van Der Waals,
Nora Douwes-Idema,
H. Mattie,
R. van Furth
Publication year - 1988
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.32.9.1456
Subject(s) - etoposide , cloxacillin , bacteria , in vitro , microbiology and biotechnology , antibiotics , antibacterial agent , gram negative bacteria , biology , pharmacology , chemistry , medicine , chemotherapy , biochemistry , escherichia coli , ampicillin , genetics , gene
Etoposide, an antitumor drug, had an effect in vitro against all strains of gram-positive bacteria studied but not against three gram-negative bacteria. The MICs ranged between 6.2 and 50 micrograms/ml. In short-term-growth experiments, etoposide had a bactericidal efficacy that was 10 to 50 times lower than that of cloxacillin.