Open AccessClinical isolate of Citrobacter freundii highly resistant to new quinolones
Author(s) -
Hiroshi Aoyama,
Kazuo Fujimaki,
Kenichi Sato,
Tatsuya Fujii,
Matsuhisa Inoue,
Keiji Hirai,
Susumu Mitsuhashi
Publication year - 1988
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.32.6.922
Subject(s) - norfloxacin , citrobacter freundii , ofloxacin , dna gyrase , microbiology and biotechnology , citrobacter , quinolone , antibacterial agent , ciprofloxacin , drug resistance , biology , enterobacteriaceae , escherichia coli , antibiotics , biochemistry , gene
About 30% of 150 recent clinical isolates of Citrobacter freundii were resistant to greater than or equal to 3.13 micrograms of norfloxacin and ofloxacin per ml. Study of one quinolone-resistant strain for which the norfloxacin MIC was 100 micrograms/ml suggested that resistance was associated with both an altered A subunit of DNA gyrase and reduction in drug uptake accompanied by a decrease in an outer membrane protein.