Clinical isolate of Citrobacter freundii highly resistant to new quinolones | Zendy

Hiroshi Aoyama | Zendy; Kazuo Fujimaki | Zendy; Kenichi Sato | Zendy; Tatsuya Fujii | Zendy; Manabu Inoue | Zendy; Keiji Hirai | Zendy; S Mitsuhashi | Zendy

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Clinical isolate of Citrobacter freundii highly resistant to new quinolones

Author(s) -

Hiroshi Aoyama,

Kazuo Fujimaki,

Kenichi Sato,

Tatsuya Fujii,

Manabu Inoue,

Keiji Hirai,

S Mitsuhashi

Publication year - 1988

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.32.6.922

Subject(s) - norfloxacin , citrobacter freundii , ofloxacin , dna gyrase , microbiology and biotechnology , citrobacter , quinolone , antibacterial agent , ciprofloxacin , drug resistance , biology , enterobacteriaceae , escherichia coli , antibiotics , biochemistry , gene

About 30% of 150 recent clinical isolates of Citrobacter freundii were resistant to greater than or equal to 3.13 micrograms of norfloxacin and ofloxacin per ml. Study of one quinolone-resistant strain for which the norfloxacin MIC was 100 micrograms/ml suggested that resistance was associated with both an altered A subunit of DNA gyrase and reduction in drug uptake accompanied by a decrease in an outer membrane protein.

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