Effect of aminoglycoside concentration on reaction rates of aminoglycoside-modifying enzymes | Zendy

G.P.A. Bongaerts | Zendy; J Vliegenthart | Zendy

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Effect of aminoglycoside concentration on reaction rates of aminoglycoside-modifying enzymes

Author(s) -

G.P.A. Bongaerts,

J Vliegenthart

Publication year - 1988

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.32.5.740

Subject(s) - aminoglycoside , substrate (aquarium) , enzyme , saturation (graph theory) , chemistry , enzyme kinetics , biochemistry , antibiotics , biology , mathematics , active site , ecology , combinatorics

Reaction rates of several reference aminoglycoside-modifying enzymes were studied at various substrate concentrations. The resulting concentration-response curves showed wide variation in threshold concentration, in curve slope, in enzyme saturation, and in substrate inhibition. Together, the curves of a defined aminoglycoside panel yielded more specific information for each individual aminoglycoside-modifying enzyme tested than did conventional substrate profiles obtained at a single substrate concentration.

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