Open AccessIn vitro evaluation of josamycin, spiramycin, and erythromycin against Rickettsia rickettsii and R. conorii
Author(s) -
Didier Raoult,
P. Roussellier,
J Tamalet
Publication year - 1988
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.32.2.255
Subject(s) - josamycin , spiramycin , rickettsia rickettsii , erythromycin , rickettsia conorii , microbiology and biotechnology , boutonneuse fever , biology , virology , rickettsiosis , antibiotics , spotted fever , rickettsia , virus
The antimicrobial activities of josamycin, erythromycin, and spiramycin against Rickettsia conorii and R. rickettsii were evaluated in two tests: a dye-uptake assay and a plaque assay. The MIC of josamycin was 1 microgram/ml for both species; the MICs of erythromycin and spiramycin were 4 to 8 and 16 to 32 micrograms/ml, respectively, for both species. Only josamycin may be of clinical use in treating spotted fever rickettsiosis. It may be useful in treating pregnant women and young children.