Role of beta-lactamase in expression of resistance by methicillin-resistant Staphylococcus aureus | Zendy

John M. Boyce | Zendy; Antone A. Medeiros | Zendy

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Role of beta-lactamase in expression of resistance by methicillin-resistant Staphylococcus aureus

Author(s) -

John M. Boyce,

Antone A. Medeiros

Publication year - 1987

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.31.9.1426

Subject(s) - staphylococcus aureus , microbiology and biotechnology , penicillin binding proteins , antibiotics , penicillin , beta lactamase , penicillin resistance , beta lactam , micrococcaceae , beta (programming language) , biology , staphylococcus , staphylococcal infections , methicillin resistant staphylococcus aureus , bacteria , antibiotic resistance , gene , antibacterial agent , escherichia coli , genetics , computer science , programming language

Of 27 unique clinical isolates of methicillin-resistant Staphylococcus aureus, only 4 were homogeneously resistant, and all 4 produced little or no beta-lactamase. Among heterogeneously resistant strains, those most resistant to beta-lactam antibiotics produced the most beta-lactamase. Similar genes may regulate production of the low-affinity penicillin-binding protein and beta-lactamase.

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