Open AccessRole of beta-lactamase in expression of resistance by methicillin-resistant Staphylococcus aureus
Author(s) -
John M. Boyce,
Antone A. Medeiros
Publication year - 1987
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.31.9.1426
Subject(s) - staphylococcus aureus , microbiology and biotechnology , penicillin binding proteins , antibiotics , penicillin , beta lactamase , penicillin resistance , beta lactam , micrococcaceae , beta (programming language) , biology , staphylococcus , staphylococcal infections , methicillin resistant staphylococcus aureus , bacteria , antibiotic resistance , gene , antibacterial agent , escherichia coli , genetics , computer science , programming language
Of 27 unique clinical isolates of methicillin-resistant Staphylococcus aureus, only 4 were homogeneously resistant, and all 4 produced little or no beta-lactamase. Among heterogeneously resistant strains, those most resistant to beta-lactam antibiotics produced the most beta-lactamase. Similar genes may regulate production of the low-affinity penicillin-binding protein and beta-lactamase.