Open AccessCiprofloxacin interactions with imipenem and amikacin against multiresistant Pseudomonas aeruginosa
Author(s) -
Helen Giamarellou,
George Petrikkos
Publication year - 1987
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.31.6.959
Subject(s) - amikacin , imipenem , ciprofloxacin , pseudomonas aeruginosa , microbiology and biotechnology , antibacterial agent , antibiotics , biology , medicine , bacteria , antibiotic resistance , genetics
In vitro interactions of ciprofloxacin with imipenem and amikacin were evaluated by the killing-curve technique against 26 Pseudomonas aeruginosa strains resistant to amikacin and resistant or moderately susceptible to ciprofloxacin and imipenem. Imipenem enhanced killing by ciprofloxacin in tests with 11 strains, whereas amikacin enhanced killing in tests with only 4 strains.