Open AccessEffect of dose size on bioavailability of ciprofloxacin
Author(s) -
Karen I. Plaisance,
George L. Drusano,
Alan Forrest,
Carlos I. Bustamante,
Harold C. Standiford
Publication year - 1987
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.31.6.956
Subject(s) - bioavailability , ciprofloxacin , volunteer , crossover study , pharmacology , oral administration , pharmacokinetics , medicine , adverse effect , chemistry , antibiotics , biology , biochemistry , alternative medicine , pathology , agronomy , placebo
We evaluated the bioavailability of ciprofloxacin at two dose sizes in eight healthy volunteers. Each volunteer was given 200 mg of ciprofloxacin both orally and intravenously in a randomized crossover fashion and 750 mg orally. Bioavailability at the two doses was similar: 69 and 69.1% for the 200- and 750-mg doses, respectively. However, the bioavailability observed with the 750-mg dose was significantly more variable than that observed with the 200-mg dose. Between 375 and 700 mg of ciprofloxacin reached the systemic circulation after administration of the 750-mg dose, with no evidence of adverse reactions.