Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery | Zendy

Uwe Frank | Zendy; I. Kappstein | Zendy; E. Schmidt-Eisenlohr | Zendy; V. Schlosser | Zendy; G Spillner | Zendy; M Schindler | Zendy; Franz Daschner | Zendy

Open Access

Penetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery

Author(s) -

Uwe Frank,

I. Kappstein,

E. Schmidt-Eisenlohr,

V. Schlosser,

G Spillner,

M Schindler,

Franz Daschner

Publication year - 1987

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.31.5.813

Subject(s) - ceftazidime , bolus (digestion) , medicine , intravenous bolus , muscle tissue , penetration (warfare) , anesthesia , subcutaneous tissue , pharmacokinetics , surgery , biology , genetics , bacteria , pseudomonas aeruginosa , operations research , engineering

Patients undergoing open-heart surgery were given an intravenous bolus injection of 2 g of ceftazidime as a single dose over a period of 5 min. Within 12 h, ceftazidime concentrations in serum declined from 55.8 to 3.9 mg/liter. Subcutaneous tissue concentrations of the drug decreased from 21.0 to 2.7 micrograms/g, and muscle concentrations decreased from 34.5 to 2.5 micrograms/g. Ceftazidime concentrations in cardiac valvular tissue were even higher than those in muscle or fat, declining from 37.4 to 6.3 micrograms/g within 10 h.

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