Open AccessPenetration of ceftazidime into heart valves and subcutaneous and muscle tissue of patients undergoing open-heart surgery
Author(s) -
Uwe Frank,
Ines Kappstein,
E. Schmidt-Eisenlohr,
V. Schlosser,
G Spillner,
M Schindler,
Franz Daschner
Publication year - 1987
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.31.5.813
Subject(s) - ceftazidime , bolus (digestion) , medicine , intravenous bolus , muscle tissue , penetration (warfare) , anesthesia , subcutaneous tissue , pharmacokinetics , surgery , biology , genetics , bacteria , pseudomonas aeruginosa , operations research , engineering
Patients undergoing open-heart surgery were given an intravenous bolus injection of 2 g of ceftazidime as a single dose over a period of 5 min. Within 12 h, ceftazidime concentrations in serum declined from 55.8 to 3.9 mg/liter. Subcutaneous tissue concentrations of the drug decreased from 21.0 to 2.7 micrograms/g, and muscle concentrations decreased from 34.5 to 2.5 micrograms/g. Ceftazidime concentrations in cardiac valvular tissue were even higher than those in muscle or fat, declining from 37.4 to 6.3 micrograms/g within 10 h.