Comparative activity of metronidazole and tinidazole against Clostridium difficile and Peptostreptococcus anaerobius | Zendy

A M Jokipii | Zendy; Liisa Jokipii | Zendy

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Comparative activity of metronidazole and tinidazole against Clostridium difficile and Peptostreptococcus anaerobius

Author(s) -

A M Jokipii,

Liisa Jokipii

Publication year - 1987

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.31.2.183

Subject(s) - tinidazole , peptostreptococcus , metronidazole , clostridium difficile , microbiology and biotechnology , microgram , clostridium , anaerobic bacteria , chemistry , biology , antibiotics , bacteria , in vitro , biochemistry , genetics

Broth dilution MICs of metronidazole against 38 strains of Clostridium difficile (0.13 microgram/ml) and 11 strains of Peptostreptococcus anaerobius (0.11 microgram/ml) were lower than those of tinidazole (0.16 and 0.17 microgram/ml, respectively). As molar concentrations the nitroimidazoles were equally active. The MICs of the two drugs correlated positively, and the relative activity of tinidazole increased with decreasing susceptibility of both species.

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