Open AccessComparative activity of metronidazole and tinidazole against Clostridium difficile and Peptostreptococcus anaerobius
Author(s) -
A. M. M. Jokipii,
Liisa Jokipii
Publication year - 1987
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.31.2.183
Subject(s) - tinidazole , peptostreptococcus , metronidazole , clostridium difficile , microbiology and biotechnology , microgram , chemistry , antibiotics , minimum inhibitory concentration , anaerobic bacteria , biology , bacteria , in vitro , biochemistry , genetics
Broth dilution MICs of metronidazole against 38 strains of Clostridium difficile (0.13 microgram/ml) and 11 strains of Peptostreptococcus anaerobius (0.11 microgram/ml) were lower than those of tinidazole (0.16 and 0.17 microgram/ml, respectively). As molar concentrations the nitroimidazoles were equally active. The MICs of the two drugs correlated positively, and the relative activity of tinidazole increased with decreasing susceptibility of both species.